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BMC Infect Dis. 2017 Jan 26;17(1):99. doi: 10.1186/s12879-017-2214-2.

Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status.

Author information

1
Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place Louis Pasteur, 20360, Casablanca, Morocco. sayeh.ezzikouri@pasteur.ma.
2
Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, 1, Place Louis Pasteur, 20360, Casablanca, Morocco.
3
Cell Biology Department, Faculty of Sciences, Chouaib Doukkali University, El-Jadida, Morocco.
4
Virology Unit, Immunovirology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.

Abstract

BACKGROUND:

The sodium taurocholate co-transporting polypeptide, encoded by SLC10A1, was identified as a functional receptor for hepatitis B virus (HBV). The objective of this study was to determine if there was an association of the Ser267Phe variant (rs2296651) with HBV infection status in Moroccan patients.

METHODS:

Using a TaqMan 5' allelic discrimination assay, the Ser267Phe variant was genotyped in 286 chronic hepatitis B patients, 135 individuals with spontaneous clearance from HBV infection and 109 healthy controls negative for hepatitis B serological markers.

RESULTS:

In this cohort, we detected only wild-type genotype (S267S) in all groups. This polymorphism was not associated with the HBV infection status in Moroccan patients.

CONCLUSIONS:

The S267F variant is absent among Moroccans regardless of chronic HBV infection status.

KEYWORDS:

Functional receptor; Hepatitis B virus; NTCP; Polymorphism

PMID:
28125961
PMCID:
PMC5270288
DOI:
10.1186/s12879-017-2214-2
[Indexed for MEDLINE]
Free PMC Article

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