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Neurosci Lett. 1989 Jul 31;102(2-3):185-90.

Neuronal death in the developing sexually dimorphic periventricular nucleus of the preoptic area in the female rat: effect of neonatal androgen treatment.

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Department of Anatomy, Juntendo University School of Medicine, Tokyo, Japan.


Neonatal treatment of female rats with androgen decreases the nuclear volume of the anteroventral periventricular nucleus of the preoptic area (AVPv-POA). In order to examine the effect of androgen on the neural substrates in the developing AVPv-POA which show a sexual dimorphism in nuclear volume, the cell death pattern in the AVPv-POA was compared between normal females and androgenized females. Wistar female rats were treated with 50 micrograms of testosterone propionate (TP) for 5 days from the day of birth. Degenerating cells (pyenotic cells) and normal cells were counted in every third section from days 1 to 13 of life. The rate of pycnotic cells to 1000 cells in TP-treated females sacrificed at days 7 and 10 was significantly higher than that in normal females. These results may suggest that neonatal androgen regulates neuronal death in the AVPv-POA, decreasing the number of neurons in the nucleus.

[Indexed for MEDLINE]

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