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Exp Ther Med. 2017 Jan;13(1):146-154. doi: 10.3892/etm.2016.3929. Epub 2016 Nov 25.

Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice.

Author information

1
Department of Physiology, College of Korean Medicine, Dongeui University, Busan 614-851, Republic of Korea.
2
Department of Biochemistry, College of Korean Medicine, Dongeui University, Busan 614-851, Republic of Korea.
3
NOVAREX Co., Ltd. Life Science R&D Institute, Ochang, Chungcheongbuk 363-885, Republic of Korea.
4
Department of Anatomy, College of Medicine, Kosin University, Busan 602-703, Republic of Korea.
5
Anti-Aging Research Center and Blue-Bio Industry RIC, Dongeui University, Busan 614-714, Republic of Korea; Departments of Life Science and Biotechnology, Dongeui University, Busan 614-714, Republic of Korea.
6
Department of Biochemistry, College of Korean Medicine, Dongeui University, Busan 614-851, Republic of Korea; Anti-Aging Research Center and Blue-Bio Industry RIC, Dongeui University, Busan 614-714, Republic of Korea.
7
Research Center for Anti-Aging Technology Development, Busan 609-735, Republic of Korea; Department of Biochemistry, College of Medicine, Pusan National University, Yangsan, Gyeongsangnam 626-870, Republic of Korea.

Abstract

Styphnolobium japonicum (L.) is utilized in Korean medicine for the treatment of various inflammatory diseases. The aim of the present study was to explore the effects of Fructus sophorae extract (FSE) isolated from the dried ripe fruit of S. japonicum (L.) on the development of type II collagen-induced arthritis (CIA) in BALB/c mice. The CIA mice were orally administered FSE or saline daily for 2 weeks. The incidence and severity of disease and the inflammatory response in the serum and the joint tissues were assessed. Macroscopic and histological investigation indicated that FSE protected against CIA development. FSE was associated with a significant reduction in the levels of total immunoglobulin G2a and proinflammatory cytokines and mediators in the serum. In addition, FSE suppressed the gene expression levels of proinflammatory cytokines and mediators, the mediator of osteoclastic bone remodeling, the receptor activator of nuclear factor κ-B ligand and matrix metalloproteinases in the joint tissues. The present results suggest that FSE may protect against inflammation and bone damage, and would be a valuable candidate for further investigation as a novel anti-arthritic agent.

KEYWORDS:

Fructus sophorae extract; Styphnolobium japonicum L.; type II collagen-induced arthritis

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