Format

Send to

Choose Destination
J Laryngol Otol. 2017 Mar;131(3):221-226. doi: 10.1017/S0022215117000147. Epub 2017 Jan 26.

Effects of agmatine sulphate on facial nerve injuries.

Author information

1
Department of Otorhinolaryngology,Cukurova University,Adana,Turkey.
2
Department of Histology,Faculty of Medicine,Cukurova University,Adana,Turkey.
3
Department of Clinical Pharmacy,Faculty of Pharmacy,Cukurova University,Adana,Turkey.

Abstract

OBJECTIVE:

To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy.

METHODS:

The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination.

RESULTS:

Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004).

CONCLUSION:

Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration.

KEYWORDS:

Agmatine; Facial Nerve; Nerve Regeneration

PMID:
28122652
DOI:
10.1017/S0022215117000147
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Cambridge University Press
Loading ...
Support Center