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Allergy. 2017 Jul;72(7):1006-1021. doi: 10.1111/all.13132. Epub 2017 Apr 12.

Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology.

Author information

1
Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy.
2
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
3
Drug Hypersensitivity and Desensitization Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
4
Allergy Unit, Regional University Hospital of Malaga-IBIMA, UMA, Malaga, Spain.
5
Division of Allergy & Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
6
Institute of Pharmacology, University of Bern, Bern, Switzerland.
7
Department of Dermatology and Allergy Centre, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark.
8
Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
9
Allergy Clinic, Copenhagen University Hospital at Gentofte Hospital, Copenhagen, Denmark.
10
Icahn School of Medicine at Mount Sinai, New York, NY, USA.
11
Klinik für Dermatologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.
12
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
13
Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, USA.

Abstract

This consensus document summarizes the current knowledge on the potential for precision medicine in food allergy, drug allergy, and anaphylaxis under the auspices of the PRACTALL collaboration platform. PRACTALL is a joint effort of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology, which aims to synchronize the European and American approaches to allergy care. Precision medicine is an emerging approach for disease treatment based on disease endotypes, which are phenotypic subclasses associated with specific mechanisms underlying the disease. Although significant progress has been made in defining endotypes for asthma, definitions of endotypes for food and drug allergy or for anaphylaxis lag behind. Progress has been made in discovery of biomarkers to guide a precision medicine approach to treatment of food and drug allergy, but further validation and quantification of these biomarkers are needed to allow their translation into practice in the clinical management of allergic disease.

KEYWORDS:

allergy; anaphylaxis; endotype; phenotype; precision medicine

PMID:
28122115
DOI:
10.1111/all.13132
[Indexed for MEDLINE]

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