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Med Sci (Paris). 2017 Jan;33(1):32-38. doi: 10.1051/medsci/20173301006. Epub 2017 Jan 25.

[Implants for drug substance delivery].

[Article in French]

Author information

1
Université de Lille, Inserm, U1008, CHU de Lille, Controlled Drug Delivery Systems and Biomaterials, Faculté des Sciences Pharmaceutiques et Biologiques de Lille, F-59000 Lille, France.

Abstract

Implants for controlled drug delivery can be very helpful to improve the therapeutic efficacy of a medical treatment, and at the same time reduce the risk of toxic side effects. In this article, four different strategies are exemplarily presented: hybrid bone substitutes combining hydroxyapatite and chitosan hydrogels; vascular stents coated with a bio-inspired polymer; cochlear implants for local dexamethasone delivery; and in-situ forming implants for periodontitis treatment. But this is only a restricted selection, and numerous other approaches and applications based on implants releasing a drug (or a combination of drugs) exist. Compared to conventional implants or pharmaceutical dosage forms, they might offer decisive advantages.

PMID:
28120753
DOI:
10.1051/medsci/20173301006
[Indexed for MEDLINE]
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