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Nature. 1989 Nov 2;342(6245):45-50.

Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.

Author information

1
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322.

Abstract

The Caenorhabditis elegans gene unc-22 encodes a very large muscle protein, called twitchin, which consists of a protein kinase domain and several copies of two short motifs. The sequence of twitchin has unexpected similarities to the sequences of proteins of the immunoglobulin superfamily, cell adhesion molecules and vertebrate muscle proteins, including myosin light-chain kinase. These homologies, together with results from earlier genetic and molecular analyses, indicate that twitchin is involved in a novel mechanism of myosin regulation.

PMID:
2812002
DOI:
10.1038/342045a0
[Indexed for MEDLINE]

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