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Front Neurosci. 2017 Jan 10;10:617. doi: 10.3389/fnins.2016.00617. eCollection 2016.

UNC-Emory Infant Atlases for Macaque Brain Image Analysis: Postnatal Brain Development through 12 Months.

Author information

1
Department of Psychiatry, University of North Carolina Chapel Hill, NC, USA.
2
Kitware Inc. Carrboro, NC, USA.
3
Department of Psychiatry, University of North CarolinaChapel Hill, NC, USA; Department of Computer Science, University of North CarolinaChapel Hill, NC, USA.
4
Division of Autism and Related Developmental Disabilities, Department of Pediatrics, Marcus Autism Center, Children's Healthcare of Atlanta, Emory School of Medicine Atlanta, GA, USA.
5
Yerkes National Primate Research Center, Emory University Atlanta, GA, USA.
6
Department of Bioengineering, University of California, Riverside Riverside, CA, USA.
7
Department of Child Psychology, Institute of Child Development, University of Minnesota Minneapolis, MN, USA.
8
Yerkes National Primate Research Center, Emory UniversityAtlanta, GA, USA; Department of Psychiatry and Behavioral Sciences, Emory UniversityAtlanta, GA, USA.

Abstract

Computational anatomical atlases have shown to be of immense value in neuroimaging as they provide age appropriate reference spaces alongside ancillary anatomical information for automated analysis such as subcortical structural definitions, cortical parcellations or white fiber tract regions. Standard workflows in neuroimaging necessitate such atlases to be appropriately selected for the subject population of interest. This is especially of importance in early postnatal brain development, where rapid changes in brain shape and appearance render neuroimaging workflows sensitive to the appropriate atlas choice. We present here a set of novel computation atlases for structural MRI and Diffusion Tensor Imaging as crucial resource for the analysis of MRI data from non-human primate rhesus monkey (Macaca mulatta) data in early postnatal brain development. Forty socially-housed infant macaques were scanned longitudinally at ages 2 weeks, 3, 6, and 12 months in order to create cross-sectional structural and DTI atlases via unbiased atlas building at each of these ages. Probabilistic spatial prior definitions for the major tissue classes were trained on each atlas with expert manual segmentations. In this article we present the development and use of these atlases with publicly available tools, as well as the atlases themselves, which are publicly disseminated to the scientific community.

KEYWORDS:

automatic segmentation; computational atlases; diffusion tensor imaging; macaque; magnetic resonance imaging; neuroimaging; non-human primate; white matter pathways

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