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Eur Neuropsychopharmacol. 2017 Mar;27(3):261-273. doi: 10.1016/j.euroneuro.2017.01.003. Epub 2017 Jan 22.

Effects of amphetamine on pro-social ultrasonic communication in juvenile rats: Implications for mania models.

Author information

1
Behavioral Neuroscience, Experimental and Biological Psychology Philipps-University of Marburg, Gutenbergstr. 18, D-35032 Marburg, Germany.
2
German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, D-37077 Göttingen, Germany.
3
Behavioral Neuroscience, Experimental and Biological Psychology Philipps-University of Marburg, Gutenbergstr. 18, D-35032 Marburg, Germany. Electronic address: markus.woehr@staff.uni-marburg.de.

Abstract

Communication is the act of information transfer between sender and receiver. In rats, vocal communication can be studied through ultrasonic vocalizations (USV). 50-kHz USV occur in appetitive situations, most notably juvenile play, likely expressing the sender׳s positive affective state. Such appetitive 50-kHz USV serve important pro-social communicative functions and elicit social exploratory and approach behavior in the receiver. Emission of 50-kHz USV can be induced pharmacologically by the administration of psychostimulant drugs, such as amphetamine. However, it is unknown whether amphetamine affects the pro-social communicative function of 50-kHz USV in the receiver. We therefore assessed dose-response effects of amphetamine (0.0mg/kg, 0.5mg/kg, 1.0mg/kg, 2.5mg/kg, 5.0mg/kg) on pro-social ultrasonic communication on both, sender and receiver, in juvenile rats. We found an inverted U-shaped effect of amphetamine on 50-kHz USV emission, with 50-kHz USV levels being strongly enhanced by moderate doses, yet less prominent effects were seen following the highest dose. Likewise, amphetamine exerted inverted U-shaped effects on social exploratory and approach behavior induced by playback of appetitive 50-kHz USV. Social approach was enhanced by moderate amphetamine doses, but completely abolished following the highest dose. Amphetamine further dose-dependently promoted the emission of 50-kHz USV following playback of appetitive 50-kHz USV, indicating more vigorous attempts to establish social proximity. Our results support an important role of dopamine in closing a perception-and-action-loop through linking mechanisms relevant for detection and production of social vocalizations. Moreover, our approach possibly provides a new means to study mania-like aberrant social interaction and communication in animal models for bipolar disorder.

KEYWORDS:

Acoustic communication; Bipolar disorder; Dopamine; Playback; Social behavior; Ultrasonic vocalizations

PMID:
28119084
DOI:
10.1016/j.euroneuro.2017.01.003
[Indexed for MEDLINE]

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