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Sleep Med Clin. 2016 Dec;11(4):525-529. doi: 10.1016/j.jsmc.2016.08.003. Epub 2016 Oct 27.

Testosterone Deficiency and Sleep Apnea.

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Mount Sinai School of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, 11 East 26th Street, 13th Floor, New York, NY 10010, USA.
NYU School of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, 462 First Avenue Room 7N24, New York, NY 10016, USA. Electronic address:


Obstructive sleep apnea (OSA) is a common condition among middle-aged men and is often associated with reduced testosterone (T) levels. OSA can contribute to fatigue and sexual dysfunction in men. There is suggestion that T supplementation alters ventilatory responses, possibly through effects on central chemoreceptors. Traditionally, it has been recommended that T replacement therapy (TRT) be avoided in the presence of untreated severe sleep apnea. With OSA treatment, however, TRT may not only improve hypogonadism, but may also alleviate erectile/sexual dysfunction.


Continuous positive airway pressure; Obstructive sleep apnea; Sexual dysfunction; Testosterone deficiency

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