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Diagn Pathol. 2017 Jan 24;12(1):13. doi: 10.1186/s13000-016-0591-2.

SESN2 correlates with advantageous prognosis in hepatocellular carcinoma.

Author information

1
Department of Thoracic Surgery and Oncology, the No. 2 Affiliated Hospital of Qiqhar Medical University, Qiqhar, 161000, China.
2
Department of Oncology, the First Hospital of Qiqhar City, Qiqhar, 161000, China.
3
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences of Qiqhar Medical University, Qiqhar, 161000, China.
4
Department of Histology and Embryology, School of Basic Medical Sciences of Qiqhar Medical University, Qiqhar, 161000, China.
5
Department of Pathology, Jiangsu Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210000, China.
6
Department of Thoracic Surgery and Oncology, the No. 2 Affiliated Hospital of Qiqhar Medical University, Qiqhar, 161000, China. lylqqhe@126.com.
7
Department of Thoracic Surgery and Oncology, the No. 2 Affiliated Hospital of Qiqhar Medical University, Qiqhar, 161000, China. bhg28k@163.com.

Abstract

BACKGROUND:

SESN2 plays important roles in the regulation of cell survival, cell protection, and tumor suppression. However, the relationship between SESN2 expression and the clinicopathological attributes of hepatocellular carcinoma (HCC) is barely investigated.

METHODS:

One-step quantitative reverse transcription PCR, Western blotting analysis in 15 fresh HCC tissues, and immunohistochemistry (IHC) analysis in a tissue microarray (TMA) containing 100 HCC cases were performed to examine SESN2 expression. Survival analyses by Cox regression method and Kaplan-Meier curve were performed to describe the overall survival of 100 HCC patients.

RESULTS:

The SESN2 expression in HCC tissues declined dramatically compared with the corresponding noncancerous tissues, and SESN2 expression was remarkably associated with HBV infection (p = 0.019), HCV infection (p = 0.001), and lymph node metastasis (p = 0.033). Survival analysis further demonstrated that SESN2 expression could serve as an independent prognostic biomarker for overall survival in univariate (p = 0.001) and multivariate analyses (p = 0.003).

CONCLUSION:

The data are the first to indicate that SESN2 might be a novel prognostic marker for HCC and that elevated SESN2 expression predicts advantageous outcomes in HCC patients.

KEYWORDS:

Hepatocellular carcinoma; IHC; SESN2; Western blotting; qPCR

PMID:
28118855
PMCID:
PMC5260065
DOI:
10.1186/s13000-016-0591-2
[Indexed for MEDLINE]
Free PMC Article

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