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J Comp Neurol. 2017 Jun 1;525(8):1922-1933. doi: 10.1002/cne.24178. Epub 2017 Mar 10.

White matter atrophy and myelinated fiber disruption in a rat model of depression.

Gao Y1,2,3, Ma J2,3, Tang J2,3, Liang X2,3, Huang CX2,3,4, Wang SR2,3, Chen LM2,3, Wang FF2,3, Tan CX2,3, Chao FL2,3, Zhang L2,3, Qiu X2,3, Luo YM2,3, Xiao Q2,3, Du L2,3,5, Xiao Q1, Tang Y2,3.

Author information

1
Department of Geriatrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing, P. R. China.
2
Department of Histology and Embryology, Chongqing Medical University, Chongqing, P. R. China.
3
Laboratory of Stem Cells and Tissue Engineering, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, P. R. China.
4
Department of Physiology, Chongqing Medical University, Chongqing, P. R. China.
5
Department of Psychiatry, The First Affiliated Hospital, Chongqing Medical University, Chongqing, P. R. China.

Abstract

Brain imaging and postmortem studies have indicated that white matter abnormalities may contribute to the pathology and pathogenesis of depression. However, until now, no study has quantitatively investigated white matter changes in depression in rats. The current study used the chronic unpredictable stress (CUS) model of depression. Body weight and sucrose preference test (SPT) scores were assessed weekly. Upon successfully establishing the CUS animal model, all animals were tested using the SPT and the open field test (OFT). Then, transmission electron microscopy and unbiased stereological methods were used to investigate white matter changes in the rats. Compared with the control group, the body weight and sucrose preference of the CUS rats were significantly decreased (p < .001, p < .001, respectively). In the OFT, the total time spent and the total distance traveled in the inner area by the CUS rats were significantly lower than those of the control group (p = .002, p = .001, respectively). The stereological results revealed that white matter volume, the total volume, and the total length and mean diameter of myelinated fibers in the white matter of the CUS rats were significantly decreased compared to the control rats (p = .042, p = .038, p = .035, p = .019, respectively). The results of this study suggested that white matter atrophy and disruption of myelinated fibers in the white matter may contribute to the pathophysiology underlying depression, which might provide new targets for the development of novel therapeutic interventions for depression.

KEYWORDS:

RRID: AB_956157; RRID: SCR_002526; chronic unpredictable stress; depression; myelinated fibers; stereology; white matter

PMID:
28118485
DOI:
10.1002/cne.24178
[Indexed for MEDLINE]

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