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Autophagy. 2017 Apr 3;13(4):767-769. doi: 10.1080/15548627.2017.1280225. Epub 2017 Jan 24.

Dietary spermidine for lowering high blood pressure.

Author information

1
a Institute of Molecular Biosciences, NAWI Graz, University of Graz , Graz , Austria.
2
b BioTechMed Graz , Graz , Austria.
3
c Department of Cardiology , Medical University of Graz , Graz , Austria.
4
d Department of Internal Medicine , Medical University of Graz , Graz , Austria.
5
e Institute of Functional and Applied Anatomy, Hannover Medical School , Hannover , Germany.
6
f Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy) , Hannover , Germany.
7
g Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences , Graz , Austria.
8
h Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers , Paris , France.
9
i Cell Biology and Metabolomics Platforms, Gustave Roussy Comprehensive Cancer Center , Villejuif , France.
10
j INSERM, U1138 , Paris , France.
11
k Université Paris Descartes, Sorbonne Paris Cité , Paris , France.
12
l Université Pierre et Marie Curie , Paris , France.
13
m Institute for Biology, Freie Universität Berlin , Berlin , Germany.
14
n NeuroCure, Charité , Berlin , Germany.
15
o Department of Cardiovascular Physiology , Ruhr University Bochum , Bochum , Germany.
16
p Department of Cell Biology and Molecular Medicine , Rutgers-New Jersey Medical School , Newark , NJ , USA.
17
q FRIAS Freiburg Institute for Advanced Studies , Department of Dermatology , Medical Center, ZBSA Center for Biological Systems Analysis, BIOSS Centre for Biological Signalling Studies, University of Freiburg , Freiburg , Germany.
18
r Department of Biology , University of Fribourg , Fribourg , Switzerland.
19
s Department of Neurology , Medical University of Innsbruck , Innsbruck , Austria.
20
t Pôle de Biologie, Hôpital Européen Georges Pompidou , Paris , France.
21
u Karolinska Institute , Department of Women's and Children's Health , Karolinska University Hospital , Stockholm , Sweden.

Abstract

Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease. Dietary spermidine elicits cardioprotective effects in aged mice through enhancing cardiac autophagy and mitophagy. In salt-sensitive rats, spermidine supplementation also delays the development of hypertensive heart disease, coinciding with reduced arterial blood pressure. The high blood pressure-lowering effect likely results from improved global arginine bioavailability and protection from hypertension-associated renal damage. The polyamine spermidine is naturally present in human diets, though to a varying amount depending on food type and preparation. In humans, high dietary spermidine intake correlates with reduced blood pressure and decreased risk of cardiovascular disease and related death. Altogether, spermidine represents a cardio- and vascular-protective autophagy inducer that can be readily integrated in common diets.

KEYWORDS:

aging; autophagy; cardiovascular disease; hypertension; polyamine; spermidine

PMID:
28118075
PMCID:
PMC5381711
DOI:
10.1080/15548627.2017.1280225
[Indexed for MEDLINE]
Free PMC Article

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