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J Magn Reson Imaging. 2017 Sep;46(3):678-689. doi: 10.1002/jmri.25616. Epub 2017 Jan 24.

Elevated adiabatic T and T in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study.

Author information

1
Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland.
2
Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.
3
Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
4
Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.
5
Infotech Oulu, University of Oulu, Oulu, Finland.
6
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.
7
Department of Internal Medicine, Mikkeli Central Hospital, Mikkeli, Finland.
8
Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA.

Abstract

PURPOSE:

To evaluate adiabatic T and T of articular cartilage in symptomatic osteoarthritis (OA) patients and asymptomatic volunteers, and to determine their association with magnetic resonance imaging (MRI)-based structural abnormalities in cartilage and bone.

MATERIALS AND METHODS:

A total of 24 subjects (age range: 50-68 years; 12 female) were enrolled, including 12 early OA patients and 12 volunteers with normal joint function. Patients and volunteers underwent 3T MRI. T2 , adiabatic T , and T relaxation times of knee articular cartilage were measured. Proton density (PD)- and T1 -weighted MR image series were also obtained and separately evaluated for morphological changes using the MRI OA Knee Scoring (MOAKS) system. Comparisons using the Mann-Whitney nonparametric test were performed after dividing the study participants according to physical symptoms as determined by Western Ontario and McMaster Universities (WOMAC) score or presence of cartilage lesions, bone marrow lesions, or osteophytes.

RESULTS:

Elevated adiabatic T and T relaxation times of articular cartilage were associated with cartilage loss (P = 0.024-0.047), physical symptoms (0.0068-0.035), and osteophytes (0.0039-0.027). Elevated adiabatic T was also associated with bone marrow lesions (0.033).

CONCLUSION:

Preliminary data suggest that elevated adiabatic T and T of cartilage are associated with morphological abnormalities of cartilage and bone, and thus may be applicable for in vivo OA research and diagnostics.

LEVEL OF EVIDENCE:

2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:678-689.

KEYWORDS:

#T2ρ; #spin-lock; T1ρ; articular cartilage; in vivo; relaxation

PMID:
28117922
DOI:
10.1002/jmri.25616
[Indexed for MEDLINE]

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