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Nutrients. 2017 Jan 21;9(1). pii: E84. doi: 10.3390/nu9010084.

Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans.

Author information

1
Wageningen Food and Biobased Research, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands. lonneke.janssen@wur.nl.
2
Nutrition and Pharmacology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands. lonneke.janssen@wur.nl.
3
Human and Animal Physiology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands. lonneke.janssen@wur.nl.
4
Nutrition and Pharmacology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands. klaske.vannorren@wur.nl.
5
Nutricia Research, P.O. Box 80141, 3508 TC Utrecht, The Netherlands. klaske.vannorren@wur.nl.
6
Human and Animal Physiology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands. sander.grefte@wur.nl.
7
Food Allergy Research and Resource Program, Food Science and Technology, University of Nebraska-Lincoln, Rm 279 Food Innovation Center, P.O. Box 886207, Lincoln, NE 68588-6207, USA. stefkoppelman@zonnet.nl.
8
Maastricht University Medical Centre, Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, P.O. Box 616, 6200 MD Maastricht, The Netherlands. kaatje.lenaerts@maastrichtuniversity.nl.
9
Human and Animal Physiology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands. jaap.keijer@wur.nl.
10
Nutrition and Pharmacology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands. renger.witkamp@wur.nl.
11
Wageningen Food and Biobased Research, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands. harry.wichers@wur.nl.

Abstract

Controlled studies on the effect of exercise on intestinal uptake of protein are scarce and underlying mechanisms largely unclear. We studied the uptake of the major allergen Ara h 6 following peanut consumption in an exercise model and compared this with changes in markers of intestinal permeability and integrity. Ten overnight-fasted healthy non-allergic men (n = 4) and women (n = 6) (23 ± 4 years) ingested 100 g of peanuts together with a lactulose/rhamnose (L/R) solution, followed by rest or by 60 min cycling at 70% of their maximal workload. Significantly higher, though variable, levels of Ara h 6 in serum were found during exercise compared to rest (Peak p = 0.03; area under the curve p = 0.006), with individual fold changes ranging from no increase to an increase of over 150-fold in the uptake of Ara h 6. Similarly, uptake of lactulose (2-18 fold change, p = 0.0009) and L/R ratios (0.4-7.9 fold change, p = 0.04) were significantly increased which indicates an increase in intestinal permeability. Intestinal permeability and uptake of Ara h 6 were strongly correlated (r = 0.77, p < 0.0001 for lactulose and Ara h 6). Endurance exercise after consumption may lead to increased paracellular intestinal uptake of food proteins.

KEYWORDS:

Ara h 6; allergen; endurance exercise; food-dependent exercise-induced anaphylaxis; intestinal permeability

PMID:
28117717
PMCID:
PMC5295128
DOI:
10.3390/nu9010084
[Indexed for MEDLINE]
Free PMC Article

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