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J Orthop Surg Res. 2017 Jan 23;12(1):16. doi: 10.1186/s13018-017-0521-3.

The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials.

Author information

1
Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China.
2
Section of Clinical Epidemiology, Institute of Orthopaedic Traumatology affiliated to Shanghai Jiaotong University, 600 Yishan Road, Shanghai, 200233, China.
3
Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China. xuetaoxie@163.com.

Abstract

BACKGROUND:

Quite a few randomized controlled trials (RCTs) investigating the efficacy of platelet-rich plasma (PRP) for treatment of knee osteoarthritis (OA) have been recently published. Therefore, an updated systematic review was performed to evaluate the temporal effect of PRP on knee pain and physical function.

METHODS:

Pubmed, Embase, Cochrane library, and Scopus were searched for human RCTs comparing the efficacy and/or safety of PRP infiltration with other intra-articular injections. A descriptive summary and quality assessment were performed for all the studies finally included for analysis. For studies reporting outcomes concerning Western Ontario and McMaster Universities Arthritis Index (WOMAC) or adverse events, a random-effects model was used for data synthesis.

RESULTS:

Fourteen RCTs comprising 1423 participants were included. The control included saline placebo, HA, ozone, and corticosteroids. The follow-up ranged from 12 weeks to 12 months. Risk of bias assessment showed that 4 studies were considered as moderate risk of bias and 10 as high risk of bias. Compared with control, PRP injections significantly reduced WOMAC pain subscores at 3, 6, and 12 months follow-up (p = 0.02, 0.004, <0.001, respectively); PRP significantly improved WOMAC physical function subscores at 3, 6, and 12 months (p = 0.002, 0.01, <0.001, respectively); PRP also significantly improved total WOMAC scores at 3, 6 and 12 months (all p < 0.001); nonetheless, PRP did not significantly increased the risk of post-injection adverse events (RR, 1.40 [95% CI, 0.80 to 2.45], I 2  = 59%, p = 0.24).

CONCLUSIONS:

Intra-articular PRP injections probably are more efficacious in the treatment of knee OA in terms of pain relief and self-reported function improvement at 3, 6 and 12 months follow-up, compared with other injections, including saline placebo, HA, ozone, and corticosteroids.

REVIEW REGISTRATION:

PROSPERO CRD42016045410 . Registered 8 August 2016.

KEYWORDS:

Hyaluronic acid; Knee; Osteoarthritis; Platelet-rich plasma; Systematic review

PMID:
28115016
PMCID:
PMC5260061
DOI:
10.1186/s13018-017-0521-3
[Indexed for MEDLINE]
Free PMC Article

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