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Biomark Med. 2017 Feb;11(2):117-124. doi: 10.2217/bmm-2016-0244. Epub 2017 Jan 23.

Association between C-reactive protein levels in the first 1-3 days post-transplant and allogeneic immune reactions.

Author information

1
Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, 11 Xizhimen South Street, Beijing 100044, PR China.

Abstract

AIM:

The purpose of this study was to determine whether C-reactive protein (CRP) in the first 1-3 days post-transplant could predict allogeneic immune reactions, including engraftment syndrome or acute graft-versus-host disease (GVHD), in pediatric haploidentical stem cell transplantation.

PATIENTS & METHODS:

The study population comprised 175 consecutive pediatric patients. Receiver operating characteristic analysis was performed to identify the cut-off CRP value.

RESULTS:

The high-CRP group (≥20.1 mg/l) was associated with an increased occurrence of engraftment syndrome (hazard ratio [HR] = 2.046; p = 0.008), II-IV acute GVHD (HR = 2.203; p = 0.001) and severe GVHD (HR = 6.371; p = 0.004).

CONCLUSION:

Our data suggest that higher CRP during the first 1-3 days post-transplant could be a predictor of allogeneic immune reactions.

KEYWORDS:

C-reactive protein; engraftment syndrome; graft-versus-host disease; haploidentical; stem cell transplantation

PMID:
28111964
DOI:
10.2217/bmm-2016-0244
[Indexed for MEDLINE]

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