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Exp Dermatol. 2017 Oct;26(10):949-951. doi: 10.1111/exd.13307. Epub 2017 Apr 21.

Overexpression of AQP3 and AQP10 in the skin exacerbates psoriasiform acanthosis.

Author information

1
Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA.
2
Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, Cleveland, OH, USA.
3
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
4
VA Medical Center, Cleveland, OH, USA.

Abstract

We previously observed that aquaporin-3 and aquaporin-10 are upregulated in the epidermis of hand dermatitis patients (Med. Hypotheses, 84, 2015, 498). To address the functional relevance of this upregulation, we overexpressed AQP3/AQP10 in mice using the human K1 promoter. Combining imiquimod with detergent-containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP3 or AQP3 and AQP10. Aquaporin overexpression also drove a trend towards greater weight loss in these animals. These data support a role for cutaneous aquaporins in the pathogenesis of dermatitis and as a potential target in their treatment.

KEYWORDS:

aquaporin-10; aquaporin-3; dermatitis; filaggrin; imiquimod

PMID:
28111811
PMCID:
PMC5577374
DOI:
10.1111/exd.13307
[Indexed for MEDLINE]
Free PMC Article

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