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Epilepsia. 2017 Feb;58(2):181-221. doi: 10.1111/epi.13634. Epub 2017 Jan 23.

Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).

Author information

1
Faculty of Medicine, School of Pharmacy and David R. Bloom Center for Pharmacy, Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
2
The National Center for Epilepsy, Sandvika, Norway.
3
Department of Pharmacology, Oslo University Hospital, Oslo, Norway.
4
Department of Pharmaceutics and Neurological Surgery, University of Washington, Seattle, Washington, U.S.A.
5
Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
6
C. Mondino National Neurological Institute, Pavia, Italy.
7
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
8
Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington, U.S.A.

Abstract

The Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII) took place in Madrid, Spain, on June 26-29, 2016, and was attended by >200 delegates from 31 countries. The present Progress Report provides an update on experimental and clinical results for drugs presented at the Conference. Compounds for which summary data are presented include an AED approved in 2016 (brivaracetam), 12 drugs in phase I-III clinical development (adenosine, allopregnanolone, bumetanide, cannabidiol, cannabidivarin, 2-deoxy-d-glucose, everolimus, fenfluramine, huperzine A, minocycline, SAGE-217, and valnoctamide) and 6 compounds or classes of compounds for which only preclinical data are available (bumetanide derivatives, sec-butylpropylacetamide, FV-082, 1OP-2198, NAX 810-2, and SAGE-689). Overall, the results presented at the Conference show that considerable efforts are ongoing into discovery and development of AEDs with potentially improved therapeutic profiles compared with existing agents. Many of the drugs discussed in this report show innovative mechanisms of action and many have shown promising results in patients with pharmacoresistant epilepsies, including previously neglected rare and severe epilepsy syndromes.

KEYWORDS:

Antiepileptic drugs; Drug development; Epilepsy; Epilepsy targets

PMID:
28111749
DOI:
10.1111/epi.13634
[Indexed for MEDLINE]
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