Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

Chung Ying Chan; Asif Noor; Catriona A McLean; Paul S Donnelly; Peter J Barnard

doi:10.1039/c6cc10066j

Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

Chem Commun (Camb). 2017 Feb 16;53(15):2311-2314. doi: 10.1039/c6cc10066j.

Authors

Chung Ying Chan¹, Asif Noor², Catriona A McLean³, Paul S Donnelly², Peter J Barnard¹

Affiliations

¹ Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia. p.barnard@latrobe.edu.au.
² School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.
³ Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.

PMID: 28111677
DOI: 10.1039/c6cc10066j

Abstract

A series of [Re(i)L(CO)₃]⁺ complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.

MeSH terms

Alzheimer Disease / diagnostic imaging*
Coordination Complexes / chemistry*
Frontal Lobe / diagnostic imaging
Humans
Ligands
Methane / analogs & derivatives*
Methane / chemistry
Microscopy, Fluorescence / methods*
Models, Molecular
Optical Imaging / methods
Plaque, Amyloid / diagnostic imaging*
Rhenium / chemistry*

Substances

Coordination Complexes
Ligands
carbene
Rhenium
Methane