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Vaccine. 2017 Feb 15;35(7):1046-1054. doi: 10.1016/j.vaccine.2017.01.006. Epub 2017 Jan 19.

Evaluation of reproductive protection against bovine viral diarrhea virus and bovine herpesvirus-1 afforded by annual revaccination with modified-live viral or combination modified-live/killed viral vaccines after primary vaccination with modified-live viral vaccine.

Author information

1
College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA. Electronic address: walzpau@auburn.edu.
2
College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
3
College of Agriculture, Auburn University, Auburn, AL 36849, USA.
4
School of Veterinary Medicine and Biomedical Sciences, University of Nebraska, Lincoln, NE 68683, USA.
5
Zoetis, INC., Florham Park, NJ 07932, USA.
6
Great Plains Veterinary Educational Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska, Clay Center, NE 68933, USA.

Abstract

The objective of this study was to compare reproductive protection in cattle against bovine viral diarrhea virus (BVDV) and bovine herpesvirus 1 (BoHV-1) provided by annual revaccination with multivalent modified-live viral (MLV) vaccine or multivalent combination viral (CV) vaccine containing temperature-sensitive modified-live BoHV-1 and killed BVDV when MLV vaccines were given pre-breeding to nulliparous heifers. Seventy-five beef heifers were allocated into treatment groups A (n=30; two MLV doses pre-breeding, annual revaccination with MLV vaccine), B (n=30; two MLV doses pre-breeding, annual revaccination with CV vaccine) and C (n=15; saline in lieu of vaccine). Heifers were administered treatments on days 0 (weaning), 183 (pre-breeding), 366 (first gestation), and 738 (second gestation). After first calving, primiparous cows were bred, with pregnancy assessment on day 715. At that time, 24 group A heifers (23 pregnancies), 23 group B heifers (22 pregnancies), and 15 group C heifers (15 pregnancies) were commingled with six persistently infected (PI) cattle for 16days. Ninety-nine days after PI removal, cows were intravenously inoculated with BoHV-1. All fetuses and live offspring were assessed for BVDV and BoHV-1. Abortions occurred in 3/23 group A cows, 1/22 group B cows, and 11/15 group C cows. Fetal infection with BVDV or BoHV-1 occurred in 4/23 group A offspring, 0/22 group B offspring, and 15/15 group C offspring. This research demonstrates efficacy of administering two pre-breeding doses of MLV vaccine with annual revaccination using CV vaccine to prevent fetal loss due to exposure to BVDV and BoHV-1.

KEYWORDS:

Bovine herpesvirus 1; Bovine viral diarrhea virus; Cattle; Reproductive protection; Vaccine efficacy

PMID:
28111144
DOI:
10.1016/j.vaccine.2017.01.006
[Indexed for MEDLINE]
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