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Biosci Biotechnol Biochem. 2017 May;81(5):1014-1017. doi: 10.1080/09168451.2017.1280661. Epub 2017 Jan 23.

Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain.

Author information

1
a Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences , Kanazawa University Graduate School of Natural Science and Technology , Kanazawa , Japan.
2
b Citrus Research Division , Institute of Fruit Tree and Tea Science, National Agriculture and Food Research Organization , Shizuoka , Japan.

Abstract

β-cryptoxanthin, a xanthophyll carotenoid, exerts preventive effects on various lifestyle-related diseases. Here, we found that daily oral administration of β-cryptoxanthin significantly ameliorated the development of tactile allodynia following spinal nerve injury but was ineffective in mechanical allodynia in an inflammatory pain model in mice. Our results suggest that β-cryptoxanthin supplementation would be beneficial for the prophylaxis of neuropathic pain.

KEYWORDS:

allodynia; neuropathic pain; β-cryptoxanthin

PMID:
28110620
DOI:
10.1080/09168451.2017.1280661
[Indexed for MEDLINE]

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