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J Infect Chemother. 2017 Aug;23(8):579-581. doi: 10.1016/j.jiac.2016.12.004. Epub 2017 Jan 19.

First clinical isolation report of azole-resistant Aspergillus fumigatus with TR34/L98H-type mutation in Japan.

Author information

1
Diagnostic Center for Animal Health and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan; Division of Clinical Research, Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8673, Japan. Electronic address: tome@obihiro.ac.jp.
2
Division of Clinical Research, Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8673, Japan.
3
Department of Medical Technologist, Obihiro-Kosei General Hospital, West 6 South 8-1, Obihiro, Hokkaido 080-0016, Japan.
4
First Department of Internal Medicine, Obihiro-Kosei General Hospital, West 6 South 8-1, Obihiro, Hokkaido 080-0016, Japan.

Abstract

Recently, azole-resistant Aspergillus fumigatus containing a 34-bp or 46-bp tandem repeat in the promoter region of cyp51A combined with amino acid substitution(s) has appeared in the environment worldwide, including several Asian countries. In this study, we isolated the 34-bp tandem repeat-containing azole-resistant A. fumigatus strain OKH50 from a patient in Japan in May 2016. The patient had not been treated with medical azoles before the strain isolation, suggesting that the resistant property was acquired before infection. In addition, the patient had not traveled overseas. Our analysis of short tandem repeats of the strain indicates that the strain is strongly related to the 34-bp tandem repeat-containing isolates from European countries and Asia-Oceania countries but not to susceptible isolates from Japan, suggesting that the strain was introduced from overseas and might spread in Japan.

KEYWORDS:

Aspergillus fumigatus; Azole; TR(34)/L98H; cyp51A

PMID:
28109740
DOI:
10.1016/j.jiac.2016.12.004
[Indexed for MEDLINE]

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