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Brain Imaging Behav. 2017 Jan 20. doi: 10.1007/s11682-016-9668-5. [Epub ahead of print]

Self-reported confusion is related to global and regional β-amyloid: data from the Women's healthy ageing project.

Author information

  • 1Centre for Medical Research, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia.
  • 2Department of Medicine, University of Melbourne, Parkville, VIC, 3050, Australia.
  • 3Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, 3084, Australia.
  • 4Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, 3050, Australia.
  • 5Centre for Medical Research, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia. cszoeke@unimelb.edu.au.
  • 6Department of Medicine, University of Melbourne, Parkville, VIC, 3050, Australia. cszoeke@unimelb.edu.au.
  • 7Institute for Health and Ageing, Melbourne, 3000, Australia. cszoeke@unimelb.edu.au.

Abstract

Disease-modifying treatments for Alzheimer's disease (AD) may require implementation during early stages of β-amyloid accumulation, well before patients have objective cognitive decline. In this study we aimed to assess the clinical value of subjective cognitive impairment (SCI) by examining the cross-sectional relationship between β-amyloid load and SCI. Cerebral β-amyloid and SCI was assessed in a cohort of 112 cognitively normal subjects. Subjective cognition was evaluated using specific questions on memory and cognition and the MAC-Q. Participants had cerebral β-amyloid load measured with 18F-Florbetaben Positron Emission Tomography (PET). No associations were found between measures of subjective memory impairment and cerebral β-amyloid. However, by self-reported confusion was predictive of a higher global β-amyloid burden (p = 0.002), after controlling for confounders. Regional analysis revealed significant associations of confusion with β-amyloid in the prefrontal region (p = 0.004), posterior cingulate and precuneus cortices (p = 0.004) and the lateral temporal lobes (p = 0.001) after controlling for confounders. An in vivo biomarker for AD pathology was associated with SCI by self-reported confusion on cross-sectional analysis. Whilst there has been a large body of research on SMC, our results indicate more research is needed to explore symptoms of confusion.

KEYWORDS:

Alzheimer’s disease; Confusion; PET imaging; Subjective cognitive impairment; Subjective memory; β-amyloid

PMID:
28108945
DOI:
10.1007/s11682-016-9668-5
[PubMed - as supplied by publisher]
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