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Eur J Pharmacol. 2017 Mar 5;798:77-84. doi: 10.1016/j.ejphar.2017.01.022. Epub 2017 Jan 18.

Emodin, a compound with putative antidiabetic potential, deteriorates glucose tolerance in rodents.

Author information

1
Division of Endocrinology & Metabolism, Department of Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address: sameid73@gmail.com.
2
Zurich University of Applied Sciences, Institute of Chemistry and Biological Chemistry, Center for Organic and Medicinal Chemistry, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland; Bacoba AG, Einsiedlerstrasse 25, 8820 Wädenswil, Switzerland. Electronic address: adams@bacoba.ch.
3
Division of Endocrinology & Metabolism, Department of Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address: thomas.scherer@meduniwien.ac.at.
4
Zurich University of Applied Sciences, Institute of Chemistry and Biological Chemistry, Center for Organic and Medicinal Chemistry, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland. Electronic address: hectormanuel.torres-gomez@zhaw.ch.
5
Division of Endocrinology & Metabolism, Department of Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address: martina.hackl@meduniwien.ac.at.
6
Division of Endocrinology & Metabolism, Department of Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address: n1635226@students.meduniwien.ac.at.
7
Zurich University of Applied Sciences, Institute of Chemistry and Biological Chemistry, Center for Organic and Medicinal Chemistry, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland. Electronic address: rira@zhaw.ch.
8
Division of Endocrinology & Metabolism, Department of Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address: anton.luger@meduniwien.ac.at.
9
Division of Endocrinology & Metabolism, Department of Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address: clemens.fuernsinn@meduniwien.ac.at.

Abstract

Emodin is found in remedies from Traditional Chinese Medicine. Since antihyperglycaemic action was observed in rodents, non-scientific sources advertise emodin intake as a natural cure for diabetes. Emodin was admixed to high fat-food of obese mice at two doses (2 and 5g/kg; daily emodin uptake 103 and 229mg/kg). Comparison was made to ad libitum fed and to food restricted control groups, the latter showing the same weight gain as the corresponding emodin-treated groups. Emodin blunted food intake by 6% and 20% for the low and high dose, which was accompanied by proportionate reductions in weight gain. Emodin reduced blood glucose relative to freely feeding controls, but comparison to weight-matched controls unmasked deterioration, rather than improvement, of basal glycaemia (mmol/l: fed ad libitum, 9.5±0.4; low emodin, 9.4±0.3, weight-matched, 8.2±0.3; high emodin, 7.2±0.4, weight-matched, 6.1±0.3; P<0.01, emodin vs weight-matched) and glucose tolerance (area under the curve, min*mol/l: fed ad libitum, 2.01±0.08; low emodin, 1.97±0.12, weight-matched, 1.75±0.03; high emodin, 1.89±0.07, weight-matched, 1.65±0.05; P<0.0002, emodin vs weight-matched). An insulin tolerance test suggested insulin desensitisation by prolonged emodin treatment. Furthermore, a single oral emodin dose did not affect glucose tolerance in obese mice, whereas intravenous injection in rats suggested a potential of emodin to acutely impair insulin release. Our results show that the antihyperglycaemic action of emodin as well as associated biochemical alterations could be the mere consequences of a spoilt appetite. Published claims of antidiabetic potential via other mechanisms evoke the danger of misuse of natural remedies by diabetic patients.

KEYWORDS:

Appetite; Body Weight; Diabetes; Emodin; Emodin (PubChem CID: 3220); Glucose

PMID:
28108376
DOI:
10.1016/j.ejphar.2017.01.022
[Indexed for MEDLINE]

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