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Complement Ther Clin Pract. 2017 Feb;26:53-60. doi: 10.1016/j.ctcp.2016.11.008. Epub 2016 Nov 25.

Effect of vitamin D supplementation on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials.

Author information

1
Family Planning Research Institute, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
2
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
3
Family Planning Research Institute, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China; Wuhan Tongji Reproductive Medicine Hospital, Wuhan, People's Republic of China. Electronic address: clxiong951@sina.com.

Abstract

OBJECTIVE:

To evaluate the effect of vitamin D supplementation on patients with PCOS.

METHODS:

We performed a literature search in database and identified all of the RCTs published before December 2015 that compared the effect of vitamin D supplementation with placebo or metformin in PCOS patients.

MAIN RESULTS:

Nine out of 463 identified studies were included, involving 502 women presenting with PCOS. Vitamin D supplementation had significant effect on the improvement of follicular development with a higher number of dominant follicles (OR, 2.34; 95% CI, 1.39 to 3.92). Differences in regular menstrual cycles were also observed when metformin plus vitamin D was compared with metformin alone (OR, 1.85; 95% CI, 1.01 to 3.39).

CONCLUSIONS:

Evidence from available RCTs suggests vitamin D supplementation may be beneficial for follicular development and menstrual cycle regulation in patients with PCOS. Additional high-quality RCTs are required to confirm the effectiveness of vitamin D on PCOS.

KEYWORDS:

Meta-analysis; PCOS; RCTs; Vitamin D

PMID:
28107851
DOI:
10.1016/j.ctcp.2016.11.008
[Indexed for MEDLINE]

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