Format

Send to

Choose Destination
Br J Haematol. 2017 Mar;176(6):888-907. doi: 10.1111/bjh.14514. Epub 2017 Jan 20.

Guidelines for screening and management of late and long-term consequences of myeloma and its treatment.

Author information

1
Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
2
Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
3
Department of Oncology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
4
University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
5
Palliative Medicine, Queen's Centre for Oncology and Haematology, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.
6
King's College Hospital NHS Foundation Trust, London, UK.
7
University College London, London, UK.
8
Myeloma UK, Edinburgh, UK.
9
University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Abstract

A growing population of long-term survivors of myeloma is now accumulating the 'late effects' not only of myeloma itself, but also of several lines of treatment given throughout the course of the disease. It is thus important to recognise the cumulative burden of the disease and treatment-related toxicity in both the stable and active phases of myeloma, some of which is unlikely to be detected by routine monitoring. We summarise here the evidence for the key late effects in long-term survivors of myeloma, including physical and psychosocial consequences (in Parts 1 and 2 respectively), and recommend the use of late-effects screening protocols in detection and intervention. The early recognition of late effects and effective management strategies should lead to an improvement in the management of myeloma patients, although evidence in this area is currently limited and further research is warranted.

KEYWORDS:

chemotherapy; haematopoietic stem cell transplantation; late effects; myeloma; quality of life

PMID:
28107574
DOI:
10.1111/bjh.14514
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley Icon for White Rose Research Online
Loading ...
Support Center