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Chem Commun (Camb). 2017 Feb 4;53(10):1723-1726. doi: 10.1039/c6cc09082f. Epub 2017 Jan 20.

A bioorthogonal 'turn-on' fluorescent probe for tracking mitochondrial nitroxyl formation.

Author information

1
Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.

Abstract

A bioreductant-resistant 'turn-on' chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

PMID:
28106175
DOI:
10.1039/c6cc09082f

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