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World J Gastroenterol. 2017 Jan 7;23(1):42-47. doi: 10.3748/wjg.v23.i1.42.

Neutropenic enterocolitis.

Author information

1
Fabio G Rodrigues, Giovanna Dasilva, Steven D Wexner, Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, FL 33331, United States.

Abstract

Neutropenic colitis is a severe condition usually affecting immunocompromised patients. Its exact pathogenesis is not completely understood. The main elements in disease onset appear to be intestinal mucosal injury together with neutropenia and the weakened immune system of the afflicted patients. These initial conditions lead to intestinal edema, engorged vessels, and a disrupted mucosal surface, which becomes more vulnerable to bacterial intramural invasion. Chemotherapeutic agents can cause direct mucosal injury (mucositis) or can predispose to distension and necrosis, thereby altering intestinal motility. This article aims to review current concepts regarding neutropenic colitis' pathogenesis, diagnosis, and management.

KEYWORDS:

Immunocompromise; Intestinal edema; Intestinal mucosal injury; Intramural invasion; Neutropenia; Neutropenic colitis; Neutropenic enterocolitis; Pathogenesis

PMID:
28104979
PMCID:
PMC5221285
DOI:
10.3748/wjg.v23.i1.42
[Indexed for MEDLINE]
Free PMC Article

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