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Br J Psychiatry. 2017 Mar;210(3):209-215. doi: 10.1192/bjp.bp.115.174961. Epub 2017 Jan 19.

Cerebral blood flow alterations specific to auditory verbal hallucinations in schizophrenia.

Author information

1
Chuanjun Zhuo, MD, PhD, Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, and Department of Psychiatry Functional Neuroimaging Laboratory, Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin; Jiajia Zhu, MD, Wen Qin, MD, Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, China; Hongru Qu, MD, Xiaolei Ma, MD, Department of Psychiatry, Tianjin Anning Hospital, Tianjin, China; Chunshui Yu, MD, Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
2
Chuanjun Zhuo, MD, PhD, Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, and Department of Psychiatry Functional Neuroimaging Laboratory, Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin; Jiajia Zhu, MD, Wen Qin, MD, Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, China; Hongru Qu, MD, Xiaolei Ma, MD, Department of Psychiatry, Tianjin Anning Hospital, Tianjin, China; Chunshui Yu, MD, Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China chunshuiyu@tijmu.edu.cn.

Abstract

BackgroundAuditory verbal hallucinations (AVHs) have been associated with deficits in auditory and speech-related networks. However, the resting-state cerebral blood flow (CBF) alterations specific to AVHs in schizophrenia remain unknown.AimsTo explore AVH-related CBF alterations in individuals with schizophrenia.MethodIn total, 35 individuals with schizophrenia with AVHs, 41 individuals with schizophrenia without AVHs and 50 controls underwent arterial spin labelling magnetic resonance imaging. The CBF differences were voxel-wise compared across the three groups.ResultsWe found AVH-specific CBF increase in the right superior temporal gyrus and caudate, and AVH-specific CBF decrease in the bilateral occipital and left parietal cortices. We also observed consistent CBF changes in both schizophrenia subgroups (i.e. those with and without AVHs) including decreased CBF in the bilateral occipital regions, the left lateral prefrontal and insular cortices, and the right anterior cingulate cortex and increased CBF in the bilateral lateral temporal regions and putamen, the left middle cingulate cortex and the right thalamus.ConclusionsThe AVH-specific CBF increases in the auditory and striatal areas and CBF reductions in the visual and parietal areas suggest that there exists a CBF redistribution associated with AVHs.

PMID:
28104737
DOI:
10.1192/bjp.bp.115.174961
[Indexed for MEDLINE]

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