Format

Send to

Choose Destination
Pathog Dis. 2017 Jan 1;75(1). doi: 10.1093/femspd/ftx005.

Staphylococcus aureus pathogenesis in diverse host environments.

Author information

1
Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA.
2
Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016 USA.

Abstract

Staphylococcus aureus is an eminent human pathogen that can colonize the human host and cause severe life-threatening illnesses. This bacterium can reside in and infect a wide range of host tissues, ranging from superficial surfaces like the skin to deeper tissues such as in the gastrointestinal tract, heart and bones. Due to its multifaceted lifestyle, S. aureus uses complex regulatory networks to sense diverse signals that enable it to adapt to different environments and modulate virulence. In this minireview, we explore well-characterized environmental and host cues that S. aureus responds to and describe how this pathogen modulates virulence in response to these signals. Lastly, we highlight therapeutic approaches undertaken by several groups to inhibit both signaling and the cognate regulators that sense and transmit these signals downstream.

KEYWORDS:

MRSA; Staphylococcus aureus; gene regulation; pathogenesis

PMID:
28104617
PMCID:
PMC5353994
DOI:
10.1093/femspd/ftx005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center