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Diab Vasc Dis Res. 2017 Mar;14(2):139-143. doi: 10.1177/1479164116679079. Epub 2017 Jan 20.

Impaired olfactory function is related to the presence of neuropathy in adults with type 1 diabetes.

Author information

1
1 Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznań, Poland.
2
2 Department of Otorhinolaryngology, Raszeja City Hospital, Poznań, Poland.
3
3 Laboratory of Neuropsychobiology, Department of Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.

Abstract

INTRODUCTION:

Olfactory dysfunction is suggested to be a clinical manifestation of central diabetic neuropathy. The aim of the study was to assess olfactory function in adult patients with type 1 diabetes.

MATERIALS AND METHODS:

A total of 106 patients with type 1 diabetes and 30 healthy subjects were included in the study. We evaluated the metabolic control of diabetes and the presence of chronic complications. Olfactory function was assessed with Sniffin' Sticks.

RESULTS:

We found a negative correlation between olfactory identification scores and body mass index ( Rs -0.2; p = 0.04) and triglycerides ( Rs = -0.2; p = 0.04). We showed lower olfactory identification scores in neuropathy group versus non-neuropathy group [8 (interquartile range, 7-9) vs 10 (interquartile range, 9-11) points; p = 0.005]. In multivariate linear regression, impaired olfaction was independently associated with neuropathy (beta, -0.3; p = 0.005). In multivariate logistic regression, diabetes duration (odds ratio, 1.06; 95% confidence interval, 1.00-1.11; p = 0.04) and olfactory identification score (odds ratio, 0.61; 95% confidence interval, 0.43-0.85; p = 0.003) were independently associated with neuropathy.

CONCLUSION:

Olfactory dysfunction is observed in patients with type 1 diabetes and diabetic peripheral neuropathy.

KEYWORDS:

Type 1 diabetes; chronic complications; neuropathy; olfactory function

PMID:
28103703
DOI:
10.1177/1479164116679079
[Indexed for MEDLINE]

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