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Am J Respir Crit Care Med. 2017 May 1;195(9):1181-1188. doi: 10.1164/rccm.201608-1691OC.

Effects of Childhood Asthma on the Development of Obesity among School-aged Children.

Author information

1
1 Department of Preventive Medicine, Division of Environmental Health and.
2
2 Department of Psychiatry, Kern Medical Center, Bakersfield, California.
3
3 Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of University of Southern California, Los Angeles, California; and.

Abstract

RATIONALE:

Asthma and obesity often occur together in children. It is unknown whether asthma contributes to the childhood obesity epidemic.

OBJECTIVES:

We aimed to investigate the effects of asthma and asthma medication use on the development of childhood obesity.

METHODS:

The primary analysis was conducted among 2,171 nonobese children who were 5-8 years of age at study enrollment in the Southern California Children's Health Study (CHS) and were followed for up to 10 years. A replication analysis was performed in an independent sample of 2,684 CHS children followed from a mean age of 9.7 to 17.8 years.

MEASUREMENTS AND MAIN RESULTS:

Height and weight were measured annually to classify children into normal, overweight, and obese categories. Asthma status was ascertained by parent- or self-reported physician-diagnosed asthma. Cox proportional hazards models were fitted to assess associations of asthma history with obesity incidence during follow-up. We found that children with a diagnosis of asthma at cohort entry were at 51% increased risk of developing obesity during childhood and adolescence compared with children without asthma at baseline (hazard ratio, 1.51; 95% confidence interval, 1.08-2.10) after adjusting for confounders. Use of asthma rescue medications at cohort entry reduced the risk of developing obesity (hazard ratio, 0.57; 95% confidence interval, 0.33-0.96). In addition, the significant association between a history of asthma and an increased risk of developing obesity was replicated in an independent CHS sample.

CONCLUSIONS:

Children with asthma may be at higher risk of obesity. Asthma rescue medication use appeared to reduce obesity risk independent of physical activity.

KEYWORDS:

asthma; children; longitudinal; medication; obesity

Comment in

PMID:
28103443
PMCID:
PMC5439015
DOI:
10.1164/rccm.201608-1691OC
[Indexed for MEDLINE]
Free PMC Article

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