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PLoS One. 2017 Jan 19;12(1):e0167262. doi: 10.1371/journal.pone.0167262. eCollection 2017.

Conspicuity of Malignant Lesions on PET/CT and Simultaneous Time-Of-Flight PET/MRI.

Author information

1
Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, California, United States of America.
2
Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, California, United States of America.
3
Department of Radiology, Stanford University, Stanford, California, United States of America.

Abstract

PURPOSE:

To compare the conspicuity of malignant lesions between FDG PET/CT and a new simultaneous, time-of-flight (TOF) enabled PET/MRI scanner.

METHODS:

All patients underwent a single-injection of FDG, followed by a dual imaging protocol consisting of PET/CT followed by TOF PET/MRI. PET/CT and PET/MRI images were evaluated by two readers independently for areas of FDG uptake compatible with malignancy, and then categorized into 5 groups (1: PET/MRI and PET/CT positive; 2: PET/MRI positive, PET/CT positive in retrospect; 3: PET/CT positive, PET/MRI positive in retrospect; 4: PET/MRI positive, PET/CT negative; 5: PET/MRI negative, PET/CT positive) by consensus. Patients with no lesions on either study or greater than 10 lesions based on either modality were excluded from the study.

RESULTS:

Fifty-two patients (mean±SD age: 58±14 years) underwent the dual imaging protocol; of these, 29 patients with a total of 93 FDG-avid lesions met the inclusion criteria. The majority of lesions (56%) were recorded prospectively in the same location on PET/CT and PET/MRI. About an equal small fraction of lesions were seen on PET/CT but only retrospectively on PET/MRI (9%) and vice versa (12%). More lesions were identified only on PET/MRI but not on PET/CT, even in retrospect (96% vs. 81%, respectively; p = 0.003). Discrepant lesions had lower maximum standardized uptake value (SUVmax) than concordant lesions on both modalities (p<0.001).

CONCLUSIONS:

While most lesions were identified prospectively on both modalities, significantly more lesions were identified with PET/MRI than with PET/CT.

PMID:
28103230
PMCID:
PMC5245859
DOI:
10.1371/journal.pone.0167262
[Indexed for MEDLINE]
Free PMC Article

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