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J Wound Care. 2017 Jan 2;26(1):20-25. doi: 10.12968/jowc.2017.26.1.20.

The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data.

Author information

1
Head of Department, Podiatric Medicine, Global Wound Biofilm Expert Panel; Liverpool Hospital, South West Sydney LHD, Australia; and Ingham Institute of Applied Medical Research, Sydney, Australia.
2
University of Copenhagen, Costerton Biofilm Center, Denmark; and Department of Clinical Microbiology, Rigshospitalet, Denmark.
3
Faculty of Biology, Medicine and Health, University of Manchester.
4
Center for Biofilm Engineering, Montana State University, US.
5
Center for Microbial Interface Biology and Department of Microbial infection, Immunity and Orthopaedics, Ohio State University, US.
6
Institute of Skin Integrity and Infection Prevention, University of Huddersfield, UK; and Imperial College, London, UK.
7
Tohoku University Graduate School of Medicine, Sendai, Japan.
8
Institute of Wound Research, Department of Obstetrics and Gynecology, College of Medicine, University of Florida.
9
South West Healthcare, Warrnambool, Victoria, Australia.
10
Southwest Regional Wound Care Centre, Lubbock Texas, US.

Abstract

The presence of biofilms in chronic non-healing wounds, has been identified through in vitro model and in vivo animal data. However, human chronic wound studies are under-represented and generally report low sample sizes. For this reason we sought to ascertain the prevalence of biofilms in human chronic wounds by undertaking a systematic review and meta-analysis. Our initial search identified 554 studies from the literature databases (Cochrane Library, Embase, Medline). After removal of duplicates, and those not meeting the requirements of inclusion, nine studies involving 185 chronic wounds met the inclusion criteria. Prevalence of biofilms in chronic wounds was 78.2 % (confidence interval [CI 61.6-89, p<0.002]). The results of our meta-analysis support our clinical assumptions that biofilms are ubiquitous in human chronic non-healing wounds.

KEYWORDS:

biofilm; infection; non-healing; systematic review; wound healing

PMID:
28103163
DOI:
10.12968/jowc.2017.26.1.20
[Indexed for MEDLINE]

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