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Int J Neurosci. 2017 Nov;127(11):953-957. doi: 10.1080/00207454.2017.1281273. Epub 2017 Feb 5.

Pregnancy and delivery in women with spinal muscular atrophy.

Author information

1
a Neurology , Johns Hopkins Aramco Healthcare , Dhahran , Saudi Arabia.
2
b Center for Biostatistics , The Ohio State University Wexner Medical Center , Columbus , OH , USA.
3
c Department of Neurology , Massachusetts General Hospital , Boston , MA , USA.
4
d Department of Neurology , The Ohio State University Wexner Medical Center, Columbus , OH , USA.
5
e Neurology Clinical Research Institute , Massachusetts General Hospital , Boston , MA , USA.

Abstract

OBJECTIVES:

To expand the limited available knowledge about pregnancy and delivery in women with spinal muscular atrophy (SMA) using a cohort of genetically proven SMA patients from USA.

METHODS:

This was a cross-sectional questionnaire-based study. We mailed questionnaires to 58 women with confirmed SMA.

RESULTS:

Thirty-two women responded, reporting 35 pregnancies, including 19 women with at least one pregnancy. In this cohort, preterm labor and delivery by cesarean section were more common in mothers with SMA particularly SMA type 2. Seventy-four percent of mothers reported increased weakness during pregnancy that persisted after delivery in 42%. SMA mothers generally had a positive experience and good outcomes and elected to have more than one pregnancy.

CONCLUSION:

This information regarding pregnancy in women with genetically confirmed 5q SMA will prove useful in guiding future research and in providing counseling to women with SMA.

KEYWORDS:

Spinal muscular atrophy; delivery complications; pregnancy course and outcome

PMID:
28102719
DOI:
10.1080/00207454.2017.1281273
[Indexed for MEDLINE]

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