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Eur J Immunol. 2017 Mar;47(3):446-453. doi: 10.1002/eji.201646716. Epub 2017 Feb 10.

TGF-β regulation of encephalitogenic and regulatory T cells in multiple sclerosis.

Author information

1
Department of Microbial Infection and Immunity, Ohio State University, Columbus, OH, USA.

Abstract

Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that has been shown to influence the differentiation and function of T cells. The role that TGF-β plays in immune-mediated disease, such as multiple sclerosis (MS), has become a major area of investigation since CD4+ T cells appear to be a major mediator of autoimmunity. This review provides an analysis of the literature on the role that TGF-β plays in the generation and regulation of encephalitogenic and regulatory T cells (Treg) in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, as well as in T cells of MS patients. Since TGF-β plays a major role in the development and function of both CD4+ effector and Treg, which are defective in MS patients, recent studies have found potential mechanisms to explain the basis for these T-cell defects to establish a foundation for potentially modulating TGF-β signaling to restore normal T-cell function in MS patients.

KEYWORDS:

Experimental autoimmune encephalomyelitis (EAE); Multiple sclerosis; T cells; TGF-β; miRNA

PMID:
28102541
PMCID:
PMC5499671
DOI:
10.1002/eji.201646716
[Indexed for MEDLINE]
Free PMC Article

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