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Biomed Opt Express. 2016 Dec 8;8(1):124-136. doi: 10.1364/BOE.8.000124. eCollection 2017 Jan 1.

Design and characterization of a combined OCT and wide field imaging falloposcope for ovarian cancer detection.

Author information

1
University of Arizona, Biomedical Engineering, 1127 James E Rogers Way, Tucson, AZ 85721, USA.
2
University of Arizona, College of Optical Sciences, 1630 East University Blvd., Tucson, AZ 85721, USA.
3
Glannaventa Inc., 2276 Allegheny Way, San Mateo, CA 94402, USA.
4
University of Arizona, Biomedical Engineering, 1127 James E Rogers Way, Tucson, AZ 85721, USA; University of Arizona, College of Optical Sciences, 1630 East University Blvd., Tucson, AZ 85721, USA.

Abstract

Early detection of ovarian cancer is only achieved in around 20% of women due to lack of effective screening. We propose a method for surveillance of high risk women based on a microendoscope introduced transvaginally to image the fallopian tubes and ovaries. This requires extreme miniaturization of the optics and catheter sheath. We describe the design of a falloposcope that combines optical coherence tomography (OCT) and wide field imaging into a sub-1 mm diameter package. We characterize the systems and show that they provide contrast on ex-vivo samples of ovary and fallopian tube. In addition, we show the mechanical performance of the endoscope in an anatomically correct model of the female reproductive tract.

KEYWORDS:

(170.2150) Endoscopic imaging; (170.3890) Medical optics instrumentation; (170.4440) ObGyn; (170.4500) Optical coherence tomography

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