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J Immunol. 2017 Mar 1;198(5):2172-2181. doi: 10.4049/jimmunol.1600165. Epub 2017 Jan 18.

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells.

Author information

1
Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1081 HZ Amsterdam, the Netherlands.
2
Department of Immunology, Monash University, Clayton, Victoria 3800, Australia.
3
Babraham Institute, Cambridge CB22 3AT, United Kingdom.
4
Nutricia Research, 3584 CT Utrecht, the Netherlands.
5
Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands; and.
6
Microbiology and Systems Biology, TNO, 3704 HE Zeist, the Netherlands.
7
Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1081 HZ Amsterdam, the Netherlands; r.mebius@vumc.nl.

Abstract

The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. In this article, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression of the vitamin A-converting enzyme RALDH1 in intestinal epithelial cells in vivo and in vitro, respectively. Furthermore, our data showed that the expression levels of RALDH1 in small intestinal epithelial cells correlated with the activity of vitamin A-converting enzymes in mesenteric lymph node dendritic cells, along with increased numbers of intestinal regulatory T cells and a higher production of luminal IgA. Moreover, we show that the consumption of dietary fiber can alter the composition of SCFA-producing microbiota and SCFA production in the small intestines. In conclusion, our data illustrate that dietary adjustments affect small intestinal epithelial cells and can be used to modulate the mucosal immune system.

PMID:
28100682
DOI:
10.4049/jimmunol.1600165
[Indexed for MEDLINE]
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