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Saudi J Kidney Dis Transpl. 2017 Jan-Feb;28(1):9-14. doi: 10.4103/1319-2442.198093.

Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial.

Author information

1
Department of Pharmacology, J. N. Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
2
Department of Medicine, J. N. Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Abstract

This study aims to evaluate efficacy and safety of Nigella sativa oil supplementation in patients with chronic kidney disease Stage 3 and 4 due to diabetic nephropathy. It was a prospective, comparative, and open-label study. Patients were randomized into two groups. Group 1 (Control) received conservative management of diabetic nephropathy, whereas Group 2 (Test) received N. sativa oil (2.5 mL, once daily and per orally) along with conservative management for 12 weeks. Blood glucose, hemogram, and kidney function test were done at 0, 6, and 12 weeks of treatment. Significance of differences between pre- and post-treatment values in each group was assessed using Student's paired t-test and between the groups using unpaired t-test. We found a drop in blood glucose, serum creatinine, blood urea, and 24 h total urinary protein levels and a rise in glomerular filtration rate, 24 h total urinary volume, and hemoglobin level in the treatment group compared to the control group.

PMID:
28098097
DOI:
10.4103/1319-2442.198093
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