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Dermatol Ther. 2017 May;30(3). doi: 10.1111/dth.12457. Epub 2017 Jan 18.

Efficacy and tolerability of amorolfine 5% nail lacquer in combination with systemic antifungal agents for onychomycosis: A meta-analysis and systematic review.

Author information

1
Department of Dermatovenerology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, 637000, China.
2
Departments of Dermatovenerology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China.

Abstract

The efficacy and safety of amorolfine 5% nail lacquer in combination with systemic antifungal agents in the treatment of the onychomycosis were evaluated. According to our meta-analysis, combination treatment of amorolfine 5% nail lacquer and systemic antifungals can result in higher percentage of complete clearance of onychomycosis. It showed that the experimental combination group was more effective than monotherapy of the systemic antifungals [OR (odds ratio) = 1.97, 95%CI (95% confidence interval) = 1.44-2.69], and no more adverse events happened with the addition of amorolfine 5% nail lacquer (OR = .96, 95%CI = .56-1.63, p = .95). This effect strengthens the fact that amorolfine 5% nail lacquer in combination with systemic antifungal agents was better than the monotherapy of systemic antifungals like itraconazole and terbinafine.

KEYWORDS:

RCT (randomized; amorolfine; combination; controlled trial); meta-analysis; onychomycosis

PMID:
28097731
DOI:
10.1111/dth.12457
[Indexed for MEDLINE]

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