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Cancer Causes Control. 2017 Feb;28(2):167-176. doi: 10.1007/s10552-016-0845-z. Epub 2017 Jan 17.

Proceedings of the third international molecular pathological epidemiology (MPE) meeting.

Author information

1
Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, Atlanta, GA, 30303, USA. peter.campbell@cancer.org.
2
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
4
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
5
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Boston, MA, USA.
6
Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
7
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
8
Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA.
9
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
10
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
11
Epidemiology and Health Services Research Group, Centre for Public Health, Queens University Belfast, Belfast, Northern Ireland.
12
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
13
Microbial Systems and Communities, Genome Sequencing and Analysis Program, The Broad Institute, Cambridge, MA, USA.
14
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
15
Laboratory Medicine and Pathology, Geisinger Health System, Danville, PA, USA.
16
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
17
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
18
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
19
Department of Biochemistry, University of Western Ontario, London, Canada.
20
University of Utah School of Medicine, Salt Lake City, UT, USA.
21
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
22
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Shuji_ogino@dfci.harvard.edu.
23
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Shuji_ogino@dfci.harvard.edu.
24
Division of MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 450 Brookline Ave, Room SM1036, Boston, MA, 02215, USA. Shuji_ogino@dfci.harvard.edu.
25
Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. Shuji_ogino@dfci.harvard.edu.

Abstract

Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods, and resources from epidemiology, pathology, biostatistics, bioinformatics, and computational biology. The underlying objective of MPE research is to better understand the etiology and progression of complex and heterogeneous human diseases with the goal of informing prevention and treatment efforts in population health and clinical medicine. Although MPE research has been commonly applied to investigating breast, lung, and colorectal cancers, its methodology can be used to study most diseases. Recent successes in MPE studies include: (1) the development of new statistical methods to address etiologic heterogeneity; (2) the enhancement of causal inference; (3) the identification of previously unknown exposure-subtype disease associations; and (4) better understanding of the role of lifestyle/behavioral factors on modifying prognosis according to disease subtype. Central challenges to MPE include the relative lack of transdisciplinary experts, educational programs, and forums to discuss issues related to the advancement of the field. To address these challenges, highlight recent successes in the field, and identify new opportunities, a series of MPE meetings have been held at the Dana-Farber Cancer Institute in Boston, MA. Herein, we share the proceedings of the Third International MPE Meeting, held in May 2016 and attended by 150 scientists from 17 countries. Special topics included integration of MPE with immunology and health disparity research. This meeting series will continue to provide an impetus to foster further transdisciplinary integration of divergent scientific fields.

KEYWORDS:

Meeting report; Molecular pathological epidemiology; Proceedings

PMID:
28097472
PMCID:
PMC5303153
DOI:
10.1007/s10552-016-0845-z
[Indexed for MEDLINE]
Free PMC Article

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