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Ann Clin Transl Neurol. 2016 Oct 20;3(12):934-939. doi: 10.1002/acn3.339. eCollection 2016 Dec.

Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.

Author information

1
Multimodal Neuroimaging Group Department of Nuclear Medicine University Hospital Cologne Cologne Germany; Cognitive Neuroscience Institute of Neuroscience and Medicine (INM-3)Research Center Jülich Jülich Germany.
2
German Center for Neurodegenerative Diseases (DZNE) Bonn Germany; Department of Psychiatry University Hospital Cologne Cologne Germany.
3
German Center for Neurodegenerative Diseases (DZNE) Bonn Germany; Department of Psychiatry and Psychotherapy University Hospital Bonn Bonn Germany.
4
Cognitive Neuroscience Institute of Neuroscience and Medicine (INM-3)Research Center Jülich Jülich Germany; Department of Neurology University Hospital Cologne Cologne Germany.
5
Multimodal Neuroimaging Group Department of Nuclear Medicine University Hospital Cologne Cologne Germany.
6
Institute of Radiochemistry and Experimental Molecular Imaging University of Cologne Cologne Germany; Institute of Neuroscience & Medicine (INM-5)Nuclear Chemistry Research Center Jülich Jülich Germany.
7
Multimodal Neuroimaging Group Department of Nuclear Medicine University Hospital Cologne Cologne Germany; German Center for Neurodegenerative Diseases (DZNE) Bonn Germany.
8
Multimodal Neuroimaging Group Department of Nuclear Medicine University Hospital Cologne Cologne Germany; Cognitive Neuroscience Institute of Neuroscience and Medicine (INM-3)Research Center Jülich Jülich Germany; German Center for Neurodegenerative Diseases (DZNE) Bonn Germany; Department of Neurology University Hospital Cologne Cologne Germany.

Abstract

In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV-1451) and beta-amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease.

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