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Int J Genomics. 2016;2016:5078796. doi: 10.1155/2016/5078796. Epub 2016 Dec 20.

The Power of CRISPR-Cas9-Induced Genome Editing to Speed Up Plant Breeding.

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Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstrasse 3, Gatersleben, 06466 Stadt Seeland, Germany.
School of Agriculture and Biology, Shanghai Jiaotong University, 800 Dong Chuan Road, Shanghai 200240, China.
Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay, Hanoi, Vietnam.


Genome editing with engineered nucleases enabling site-directed sequence modifications bears a great potential for advanced plant breeding and crop protection. Remarkably, the RNA-guided endonuclease technology (RGEN) based on the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) is an extremely powerful and easy tool that revolutionizes both basic research and plant breeding. Here, we review the major technical advances and recent applications of the CRISPR-Cas9 system for manipulation of model and crop plant genomes. We also discuss the future prospects of this technology in molecular plant breeding.

Conflict of interest statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

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