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Onco Targets Ther. 2016 Dec 23;10:129-135. doi: 10.2147/OTT.S114303. eCollection 2017.

Decreased miR-503 expression in gastric cancer is inversely correlated with serum carcinoembryonic antigen and acts as a potential prognostic and diagnostic biomarker.

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1
Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, People's Republic of China.

Abstract

BACKGROUND:

Altered expression of miR-503 has been linked to human carcinogenesis. In this present study, we aimed to detect the potential for miR-503 as a novel biomarker for gastric cancer (GC) patients.

MATERIALS AND METHODS:

The relative mRNA level of miR-503 in serum and tissue of 68 GC patients and serum of 32 healthy volunteers was determined by real-time reverse transcription quantitative polymerase chain reaction.

RESULTS:

The miR-503 level was significantly lower in the tissue and serum of GC than their counterparts (all P<0.01). Downregulation of miR-503 was found to be corrected with more aggressive tumor. Patients in the high-miR-503 group showed significantly better overall survival compared to the low-miR-503 group (P=0.021). The serum miR-503 level in GC was inversely correlated with carcinoembryonic antigen (CEA) (r=-0.624, P<0.001). Furthermore, the area under the receiver operating characteristic curve for miR-503 discriminating GC patients from healthy individuals was 0.889 (P=0.006), with a sensitivity of 96.8% and a specificity of 79.4%, higher than that of CEA (area under the receiver operating characteristic curve =0.681, P=0.048).

CONCLUSION:

The present study suggests that the expression level of miR-503 may serve as prognostic and diagnostic biomarker for GC.

KEYWORDS:

biomarker; diagnosis; gastric cancer; microRNA; prognosis

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