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J Midlife Health. 2016 Oct-Dec;7(4):169-174. doi: 10.4103/0976-7800.195695.

Prevalence of metabolic syndrome in pre- and post-menopausal women: A prospective study from apex institute of North India.

Author information

1
Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
2
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

BACKGROUND:

The metabolic syndrome (MS) (syndrome X, insulin resistance syndrome) is a constellation of metabolic abnormalities and a complex predisease state that predicts future development of type 2 diabetes mellitus and cardiovascular disease. Menopausal transition and postmenopausal state are considered as a vulnerable period for developing MS, and this increased risk has been attributed to decreasing estrogen levels with an increasing risk of insulin resistance following menopause.

AIMS AND OBJECTIVES:

This study aimed to determine the prevalence of MS and its components in pre- and post-menopausal women from North India.

METHODOLOGY:

This is a cross-sectional study of 350 women in the age group of 45-55 years attending gynecology clinic in a tertiary center of North India. Details of sociodemographic data, menopausal history, reproductive, and medical profile were obtained. Then, waist circumference, body mass index (BMI), and blood pressure were recorded. A venous blood sample was collected for fasting blood glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. MS was defined according to the modified National Cholesterol Education Program Adult Treatment Panel III criteria.

RESULTS:

The mean age was 49.09 ± 2.2 years in premenopausal and 49.54 ± 2.8 years in postmenopausal women. The prevalence of MS in the study group was 62.6%. Occurrence of MS was higher in older and obese women. Abnormal waist circumference was the most prevalent component (87%) of MS and in terms of odd ratio, correlation was highest for BMI followed by total cholesterol and waist-hip ratio.

CONCLUSION:

We should target obesity and deranged lipid profile by bringing out changes in lifestyle and dietary habits to decrease the higher prevalence of MS and the risk of cardiovascular diseases.

KEYWORDS:

Menopause; metabolic syndrome; postmenopausal women; premenopausal women

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