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J Am Soc Nephrol. 2017 May;28(5):1370-1378. doi: 10.1681/ASN.2016101077. Epub 2017 Jan 17.

(Re)Building a Kidney.

Author information

1
Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine; oxburl@mmc.org idrummond@mgh.harvard.edu.
2
Department of Molecular Biology and.
3
Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
4
Division of Kidney, Urologic, & Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
5
Institute for Molecular Engineering, University of Chicago, Chicago, Illinois.
6
Division of Nephrology, Washington University School of Medicine, St. Louis, Missouri.
7
Department of Stem Cell Biology and Regenerative Medicine and.
8
Trailhead Biosystems, Inc, Cleveland, Ohio.
9
Department of Biomedical Engineering, Tufts University, Medford, Massachusetts.
10
Epstein Department of Industrial and Systems Engineering and Information Sciences Institute, Viterbi School of Engineering and.
11
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
12
Cell Biology Theme, Murdoch Childrens Research Institute, Parkville, Melbourne, Australia.
13
Department of Pediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Melbourne, Australia.
14
Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
15
Division of Nephrology and.
16
Department of Internal Medicine, Division of Gastroenterology and.
17
Department of Cell and Developmental Biology and Center for Organogenesis, University of Michigan Medical School, Ann Arbor, Michigan.
18
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
19
Department of Surgery, Jesse Brown VA Medical Center, and.
20
Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; and.
21
Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
22
Department of Bioengineering, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle.
23
Nephrology Division, Massachusetts General Hospital, Charlestown, Massachusetts.

Abstract

(Re)Building a Kidney is a National Institute of Diabetes and Digestive and Kidney Diseases-led consortium to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and the integration of these cells into complex structures that replicate human kidney function. The ultimate goals of the consortium are two-fold: to develop and implement strategies for in vitro engineering of replacement kidney tissue, and to devise strategies to stimulate regeneration of nephrons in situ to restore failing kidney function. Projects within the consortium will answer fundamental questions regarding human gene expression in the developing kidney, essential signaling crosstalk between distinct cell types of the developing kidney, how to derive the many cell types of the kidney through directed differentiation of human pluripotent stem cells, which bioengineering or scaffolding strategies have the most potential for kidney tissue formation, and basic parameters of the regenerative response to injury. As these projects progress, the consortium will incorporate systematic investigations in physiologic function of in vitro and in vivo differentiated kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic approaches to activate innate reparative responses.

KEYWORDS:

Directed differentiation; Organogenesis; Organoid; Regeneration

PMID:
28096308
PMCID:
PMC5407737
DOI:
10.1681/ASN.2016101077
[Indexed for MEDLINE]
Free PMC Article

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