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EMBO J. 2017 Feb 15;36(4):397-408. doi: 10.15252/embj.201696010. Epub 2017 Jan 17.

Nutrient sensing and TOR signaling in yeast and mammals.

Author information

1
Biozentrum, University of Basel, Basel, Switzerland.
2
Biozentrum, University of Basel, Basel, Switzerland m.hall@unibas.ch.

Abstract

Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR) is implicated in several disorders, including cancer, obesity, and diabetes. Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR-related diseases.

KEYWORDS:

RAG ; TORC1; amino acids; glucose; mammals; nutrients; yeast

PMID:
28096180
PMCID:
PMC5694944
DOI:
10.15252/embj.201696010
[Indexed for MEDLINE]
Free PMC Article

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