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Connect Tissue Res. 2017 Nov;58(6):553-561. doi: 10.1080/03008207.2017.1281259. Epub 2017 Jan 17.

Autogenous bone particle/titanium fiber composites for bone regeneration in a rabbit radius critical-size defect model.

Author information

1
a Department of Orthopaedic Surgery , the Second Affiliated Hospital of Harbin Medical University , Harbin , China.
2
b Department of Stomatology, Zhaochunyu Dental Clinic , Harbin , China.
3
c Department of Orthopaedic Surgery, the Second Affiliated Hospital of Qiqihar Medical College , Qiqihar , China.
4
d Department of Orthopaedic Surgery, Harbin the First Hospital , Harbin , China.

Abstract

PURPOSE:

To explore the effects of autogenous bone particle/titanium fiber composites on repairing segmental bone defects in rabbits.

MATERIALS AND METHODS:

A model of bilateral radial bone defect was established in 36 New Zealand white rabbits which were randomly divided into 3 groups according to filling materials used for bilaterally defect treatment: in group C, 9 animal bone defect areas were prepared into simple bilateral radius bone defect (empty sham) as the control group; 27 rabbits were used in groups ABP and ABP-Ti. In group ABP, left defects were simply implanted with autogenous bone particles; meanwhile, group ABP-Ti animals had right defects implanted with autogenous bone particle/titanium fiber composites. Animals were sacrificed at 4, 8, and 12 weeks, respectively, after operation.

RESULTS:

Micro-CT showed that group C could not complete bone regeneration. Bone volume to tissue volume values in group ABP-Ti were better than group ABP. From histology and histomorphometry Groups ABP and ABP-Ti achieved bone repair, the bone formation of group ABP-Ti was better. The mechanical strength of group ABP-Ti was superior to that of other groups.

CONCLUSIONS:

These results confirmed the effectiveness of autologous bone particle/titanium fiber composites for promoting bone regeneration and mechanical strength.

KEYWORDS:

Autogenous bone particles; bone regeneration; fiber reinforcement; titanium fiber

PMID:
28095112
DOI:
10.1080/03008207.2017.1281259
[Indexed for MEDLINE]

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