Format

Send to

Choose Destination
Exp Dermatol. 2017 Sep;26(9):838-840. doi: 10.1111/exd.13295. Epub 2017 Apr 20.

In silico prediction of Leishmania major-specific CD8+ epitopes.

Author information

1
Department of Dermatology, Johannes Gutenberg-University, Mainz, Germany.
2
Institute of Immunology, Johannes Gutenberg-University, Mainz, Germany.
3
Department of Immunology, Paul-Ehrlich-Institute, Langen, Germany.
4
Institute of Immunology, Universitätsklinikum Tübingen, Tübingen, Germany.

Abstract

Infections with Leishmania (L.) major induce protective IFN-γ-dependent Th1/Tc1 immunity in C57BL/6 mice as well as in immunocompetent humans. Even though antigen-specific immunity provides lifelong immunity against reinfection, a vaccine against this pathogen does not yet exist. Here, we compared the results obtained from in silico predictions of murine CD8-specific L. major peptides using the algorithm SYFPEITHI with the number and predicted affinity of known proteins/peptides. Our results indicate that the majority of "immunodominant" epitopes of L. major have not been identified so far; thus, computer-based prediction algorithms may aid the development of an effective vaccine.

KEYWORDS:

L. major ; SYFPEITHI ; epitope-prediction

PMID:
28094883
DOI:
10.1111/exd.13295
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center